|
KMID : 0380219810140020101
|
|
Journal of Biochemistry and Molecular Biology
1981 Volume.14 No. 2 p.101 ~ p.112
|
|
|
Studies on Antineoplastic Components of Korean Basidiomycetes
|
|
Kang Chang-Yul
Shim Mi-Ja
Choi Eung-Chil
Lee Young-Nam
Kim Byong-Kak
|
|
|
Abstract
|
|
|
|
The find antineoplastic components from Korean higher fungi, the mycelium of Ganoderma lucidum (Fr.) Karsten was grown in shake culture and a protein-bound polysaccharide was isolated. This component suppressed tumor growth of sarcoma 180 grafted in A-strain mice. The component was administered intraperitoneally to the mice at a does of 50 mg/kg daily for five days. Ten days later, the mice were immunized with 1×10^(7) sheep red blood cells. The number of plaque-forming cells in their spleen was significantly greater than that of control mice. Three monosaccharides and sixteen amino acids were identified from the protein-bound polysaccharide.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|